Likely Madam Lisa Giocondo,AKA Mona Lisa,a masterpiece painted by Leonardo da Vinci between 1503 and 1506. The painting was created in Florence, Italy, and depicts a woman believed to be Lisa Gherardini, the wife of Francesco del Giocondo. One of the most notable features of Mona Lisa is the mastery of sfumato, a technique involving subtle tonal gradations in color that creates an almost hazy or smoky effect. This technique gives the painting its mysterious aura. Mona Lisa’s enigmatic expression has received considerable attention over time. The secret behind Mona Lisa's enigmatic smile has been explained by scientists who believe that her smile changes depending on which part of the eye sees it first. One of the charms of the world's most famous painting is that she appears radiant one moment and then serious and sardonic the next moment. As the topic transcended historians and scientists still to this date, let’s just give her a break, a lollypop and move on.